Dr. Luke Bloy

Research Staff
Luke Bloy, Ph.D. Research Scientist

Dr. Bloy has over 10 years of experience developing analysis tools and methods used to perform pediatric neuroimaging research. Much of his past research has focused on diffusion image analysis, multimodal image registration and developing quality assurance tools. His current research centers on finding technical ways to make participating in MEG research easier and less stressful for participants. Dr. Bloy looks for ways to improve our ability to use MEG to study less compliant subjects, such as infants or low functioning pediatric subjects. This includes developing improved analysis methods (motion correction/artifact rejection) as well as techniques for real-time 3D head modeling for use in MEG source localization.

Luke Bloy, Ph.D.

Related Publications

  • 47,XYY syndrome (XYY) is a male sex chromosome disorder where individuals have an X chromosome and two copies of the Y chromosome. XYY is associated with a physical phenotype and carries increased risk of neurodevelopmental disorders such as autism spectrum disorder (ASD). Latencies of auditory evoked responses measured by magnetoencephalography have shown atypical prolongations in several neuropsychiatric and genetic disorders; specifically, delayed auditory responses have been observed in ASD. In this study, we investigated the associations of genotype and clinical phenotype with auditory processing. Whole cortex magnetoencephalography recorded during a passive auditory paradigm (500 Hz tones) was used to assess the auditory evoked response in three groups of male children: idiopathic ASD, typically developing, and XYY boys. Response waveforms were computed for left and right auditory cortex and latencies of the ∼50 ms (M50) and ∼100 ms (M100) components were determined. M50 latencies were significantly delayed compared with typically developing controls in children with ASD in the right hemisphere only, and in children with XYY in the left hemisphere only, irrespective of whether they met diagnostic criteria for ASD. Findings on the later M100 component trended in the same directions but did not attain significance, due to increased variance. Replicating previous findings, decreased M50 and M100 latencies with age were observed bilaterally. Overall, while XYY shares an electrophysiological phenotype (delayed evoked response latency) with idiopathic ASD, the hemispheric differences warrant further investigation.

  • Matsuzaki J., Ku M., Berman JI., Blaskey L., Bloy L., Chen YH., Dell J., Edgar JC., Kuschner ES., Liu S., Saby J., Brodkin ES., Roberts TPL. Abnormal auditory mismatch fields in adults with autism spectrum disorder. Neuroscience letters, 2018, 698:140-145. Doi: 10.1016/j.neulet.2018.12.043. PMID: 30599264